HYPOTHESES Biological Engineering

According to the original results of Horrobin and Manku from 1977.

plateau + bell-s.jpg, Apr 2022

A theoretical model of biochemical control engineering based on the relation between oestrogens/progestagens and prostaglandins


A biological complex organism is involuntarily guided from all sides by measure and regulation systems. The human being is such a complex organism. Many cyclical processes are simultaneously at work, making it unclear how and why which process takes place at which moment. Noticeable examples are the 28-day menstrual cycle and the 40-week pregnancy. The time of activation in the middle of the menstrual is fairly clear. Hormonal changes also occur in this period. Why the hormonal changes occur, and what their relationship is with the activation of the processes is unclear. That is also the case during pregnancies. What is it that determines that a pregnancy should last an average of 40 weeks? What causes the changes in a complicated pregnancy? What are those changes? Prostaglandin concentrations have been found to have some relationship with these changes, but the activation of these changes and how to examine them is unknown.

Using an example from practical experience, this article illustrates what Horrobin and Manku already reported in 1977, namely, the properties of prostaglandin E1 and 6-keto pgF1α: reversal effect with elevated concentration. The properties described is exceptionally suitable for the time of activation in a biochemically regulated measure and regulation system. These properties can help explain the occurrence of physiological cycles. The known electronic saw-tooth wave has a biochemical analogue with this.

This paper describes the presumed relationship between hormones and the accompanying prostaglandins with the hormone effects based on what is known regarding their concentrations progress. This relationship reveals the practical consequences of the experimentally found sensitivity of biochemical effects with regard to the accompanying prostaglandins. This paper shows how the theoretical relationship between effects of oestrogens and progestagens result in a curve that comprise observable aspects of the Basal Body Temperature Curve.

The modulating and activating prostaglandins also affect local changes in blood circulation. These changes are visible on specific sites on the abdominal skin via visceral-cutaneous reflex pathways.

Changes in blood circulation at specific areas of the skin can be representative of pain. Pain that also frequently arises during activation processes. These changes can be seen and measured with non-contactual infra-red Thermography on the cutaneous surface, and moments of activation and pain can be determined.

DOI: http://dx.doi.org/10.1016/j.mehy.2015.02.021 Publication stage:Final version published online: 29-APR-2015 Full bibliographic details: Medical Hypotheses 84 (2015), pp. 557-569 DOI information: 10.1016/j.mehy.2015.02.021


P.H.E. van der Veen.

Published on 28/10/2016 by Henk